BioXcell.BE0131-25MG InVivoMab anti-mouse CTLA-4 (CD152)

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货品编号：BioXcell.BE0131-25MG

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品牌：bioxcell
所属分类：细胞分离

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        货品编号：  BioXcell.BE0131-25MG       品牌：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">BioXcell      品名：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">InVivoMab anti-mouse CTLA-4 (CD152)      规格：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">25MG</div><span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">      产品描述：      The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152.      CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily.      CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein,      CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4      negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological     tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation     has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a      lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through      immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to     the B7 co-receptors, allowing for CD28 binding.

BioXcell.BE0131-25MG InVivoMab anti-mouse CTLA-4 (CD152)

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