BioXcell.BE0146-25MG InVivoMab anti-mouse PD-1 (CD279)

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279.

销售价：

市场价：
会员价： 最低起 更多会员价
商品评分： (共0人评论)

(产品信息仅供参考，请与客服确认实际情况后再下单)

货品编号：BioXcell.BE0146-25MG

数量： -+ 支

正品货源质量保障

商品详情

品牌：bioxcell
所属分类：细胞分离

<div>
 
        货品编号：  BioXcell.BE0146-25MG       品牌：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">BioXcell      品名：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">InVivoMab anti-mouse PD-1 (CD279)      规格：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">25MG</div><span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> 
     产品描述：      The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55
     kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently 
     expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. PD-1 expression declines 
     after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell
     stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates 
     TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 
     signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known
     to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 knockout animals show dilated 
     cardiomyopathy, splenomegaly, and loss of peripheral tolerance. Induced PD-L1 expression is common in many tumors including 
     squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. PD-L1 overexpression results in increased resistance 
     of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment 
     with antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 mediated immunotherapies 
     are currently being explored as cancer treatments. Like the J43 antibody the RMP1-14 antibody has been shown to block the binding of 
     both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

BioXcell.BE0146-25MG InVivoMab anti-mouse PD-1 (CD279)

商品详情

商品评论

商品咨询

畅销排行TOP10

Axygen SCT-10ML-S，10ml无色透明运输管，样品保存管，螺旋盖，聚丙烯材质，灭菌包装，25个/包，20包/箱

Medicom 2315，Safe+Mask®一次性医用外科口罩（耳挂），灭菌包装，5个/包，300包/箱

solelybio.SBM12309 唾液采集器支

Corning 3513，12孔细胞培养板，透明，TC表面，1个/包，50包/箱

SolelyBio.SBM05678 500ml样品瓶

Solelybio.SBM07687 LB营养琼脂平板（单层包装）

solelybio.SBM06338 定制钛合金螺丝杆

海氏海诺.A106 医用口罩 10个/袋

Millipore.SLHVR33RB Millex-GP针头滤器（SLHV033RB），0.45µm，33 mm 黄色 250个/盒

Millipore SLGP033RS，Millex-GP 过滤器，孔径：0.22µm，PES膜，外径：33mm，，50个/盒

您最近浏览过的商品

新手上路

购物指南

支付/配送方式

新手上路