BioXcell.BE0131-50MG InVivoMab. anti-mouse CTLA-4 (CD152) 50 mg

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货品编号：BioXcell.BE0131-50MG

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品牌：bioxcell
所属分类：一抗

<div>     货品编号：  BioXcell.BE0131-50MG     品牌：  BioXcell     品名：  InVivoMab. anti-mouse CTLA-4 (CD152)	     规格：  50 mg      产品描述：</div>     The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known      as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28      family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally     similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1      (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses.     CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and     regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated     in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative      disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through      immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking     CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.

BioXcell.BE0131-50MG InVivoMab. anti-mouse CTLA-4 (CD152) 50 mg

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