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BioXcell.BE0012-50MG InVivoMab anti- mouse (CD25-2Rc) 50 mg
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品牌: BioXcell
品名: InVivoMab anti- mouse (CD25-2Rc)
规格: 50 mg
产品描述:
The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.
IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed
on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα
has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα
binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common
gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to
inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3
antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
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