BioXcell.BE0146-50MG InVivoMab anti- mouse. PD- 1 (CD279) 50 mg

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货品编号：BioXcell.BE0146-50MG

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品牌：bioxcell
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<div>     货品编号：  BioXcell.BE0146-50MG	 
     品牌：  BioXcell
     品名：  InVivoMab anti- mouse. PD- 1  (CD279)	
     规格：  50 mg
 
     产品描述：
</div>     The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. 
     PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the
     Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B 
     lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally,
     Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes
     a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals.
     PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, 
     PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. 
     Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in 
     mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance.
     Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma,
     and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell 
     mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with 
     antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 
     mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the 
     RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

BioXcell.BE0146-50MG InVivoMab anti- mouse. PD- 1 (CD279) 50 mg

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