apexbio.B8214 Dihydrotestosterone(DHT) 25mg

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货品编号：apexbio.B8214

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品牌：APEXBIO
所属分类：信号通路研究

<div>     货品编号：  apexbio.B8214	     品牌：  apexbio     品名：  Dihydrotestosterone(DHT)   	     规格：  25mg      产品描述：</div><div>     Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor .      In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increases the expression of EGFR      and ERBB2 both in mRNA and in protein levels. In AR-positive cell，DHT additionally upregulates the levels of phosphorylation     of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment.      DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with      stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert      myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction     denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior     as assessed by rota-rod and gait analyses, and an increased lifespan.      </div>

apexbio.B8214 Dihydrotestosterone(DHT) 25mg

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