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PMA(佛波醇12-十四酸酯13-乙酸酯)是一种蛋白激酶C(PKC)的激活剂和已知的肿瘤促进剂。PMA还表现出致裂(染色体断裂)活性。
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货品编号: Sigma.P1585-1MG
品牌: Sigma
品名: PMA
规格: 1mg
产品描述:
General description PMA(佛波醇12-十四酸酯13-乙酸酯)是一种蛋白激酶C(PKC)的激活剂和已知的肿瘤促进剂。
PMA还表现出致裂(染色体断裂)活性。[1] Phorbol 12-myristate 13-acetate (PMA) can induce the activity of PLD1 (phospholipase D1) but
not PLD2 (phospholipase D2).[2]
Through the protein kinase C (PKC) signaling pathway, PMA is a tumor promoter associated with:
• gene transcription • cell growth • cell differentiation • programmed cell death • immune pathway • receptor desensitization
Phorbol 12-myristate 13-acetate is used to study:
• growth factors • hormones • cytokines-mediated regulation of cellular growth and differentiation
Application PMA has been used: • for the detection of intracellular cytokines[3] • in CellROX oxidative stress assay[4] • for Huh7 cell stimulation to investigate dipeptidyl peptidase 9 (DPP9) re-distribution[5] • as a positive control in B-cell receptor (BCR) stimulation of chronic lymphocytic leukaemia (CLL) cells[6] • in the differentiation of monocytes (THP -1) into macrophages[7]
适用于 • 作为标准品用于分子生物学研究 • 肿瘤启动子分析研究 • 促进细胞生长
Biochem/physiol Actions Potent tumor promoter; activates protein kinase C (PKC) in vivo and in vitro. 有效的肿瘤促进剂;在体内和体外激活蛋白激酶C。
Features and Benefits • Stimulation of interleukin 2 production of Jurkat cells • T-cell stimulation • Protein kinase C (PKC) activator • NF-κB Activator • Promotion of cell growth • Used in analytical studies of tumor promoters • Molecular Biology grade
Caution 光敏感的,避光保存。
Analysis Note • Stimulation of interleukin 2 production of Jurkat cells • T-cell stimulation • Protein kinase C (PKC) activator • NF-κB Activator • Promotion of cell growth • Used in analytical studies of tumor promoters • Molecular Biology grade
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