APEXBIO.A8628-100 Chloroquine diphosphate 100mg

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货品编号：APEXBIO.A8628-100

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品牌：APEXBIO
所属分类：工具酶

货品编号：  APEXBIO.A8628-100       品       牌：  <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">APEXBIO      品       名：  <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">Chloroquine diphosphate       规       格：  <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">100mg             产品描述：      Chloroquine diphosphate（氯喹宁二磷酸盐）被用作抗疟疾药物，也可通过诱导自噬，从而增加肿瘤细胞对放疗和化疗的敏感性 [1]。 <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     据报道，chloroquine diphosphate可诱导自噬，因而可作为放疗和化疗的佐剂，用于抵抗癌细胞的增殖或转移 [2]。Chloroquine diphosphate<span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     诱导细胞自噬的机制是诱导G1期停滞，上调p27和p53的表达，而下调CDK2和细胞周期蛋白D1的表达 [3]。 <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     除了抗疟疾，chloroquine diphosphate对细胞凋亡也起作用。CNE-2人鼻咽癌细胞用chloroquine diphosphate预处理后通过增加细胞自噬的比<span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     例，增强电离辐射诱导的细胞凋亡 [4]。在人结肠癌DLD-1细胞中，5-FU与chloroquine diphosphate联合治疗通过诱导自噬，抑制细胞增殖 [3]。<span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     在小鼠乳腺癌4T1细胞中，chloroquine diphosphate以时间和剂量依赖的方式抑制细胞增殖和存活，导致细胞凋亡 [2]。 <span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     在4T1细胞皮下异种移植小鼠模型中，chloroquine diphosphate显著抑制肿瘤生长和肿瘤细胞向肺部的转移，因而增加小鼠存活 [2]。在皮下注<span style="display: inline !important; float: none; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; overflow-wrap: break-word; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     射colon26细胞的BALB/c小鼠中，chloroquine diphosphate与5-FU联合治疗通过增加凋亡细胞的比例，显著增强5-FU诱导的肿瘤生长抑制 [5]。 <div>
<img src="http://www.solelybio.com/public/images/6f/cf/10/e35e7f6aae02779dcee12fa0c71a7f6ce4daddff.png?1601274015#w"><strike></strike> </div>

APEXBIO.A8628-100 Chloroquine diphosphate 100mg

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