R&D.FMK001 Pan Caspase Inhibitor Z-VAD-FMK 1mg

R&D FMK001 Pan Caspase Inhibitor Z-VAD-FMK 1mg

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货品编号：R&D FMK001

数量： -+ 支

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品牌：R&D Systems
所属分类：辅助货品

<p><div>     货品编号：  R&D.FMK001<span style="white-space: pre;">	</span></p><p>     品牌：  R&D</p><p>     品名：  Pan Caspase Inhibitor Z-VAD-FMK<span style="white-space: pre;">	</span></p><p>     规格：  1mg</p></div><p><br/></p><div><div id="ds_product_details" class="datasheet_section" style="box-sizing: border-box; padding-bottom: 20px; margin-bottom: 20px; border-bottom: 1px solid rgb(0, 95, 158); overflow: hidden; position: relative; height: auto; color: rgb(51, 51, 51); font-family: arial, sans-serif; font-size: 14px;"><p style="box-sizing: border-box; margin: 0px;">Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.</p>
</div><h3 class="subheader18" style="box-sizing: border-box; font-family: arial, sans-serif; line-height: 1; color: rgb(0, 95, 158); margin-top: 0px; margin-bottom: 15px; font-size: 18px;"></h3><p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: rgb(51, 51, 51); font-family: arial, sans-serif;"></p>
<p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: rgb(51, 51, 51); font-family: arial, sans-serif;">Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).</p>
<p style="box-sizing: border-box; margin: 0px 0px 10px; font-size: 14px; color: rgb(51, 51, 51); font-family: arial, sans-serif;">Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.</p>
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R&D.FMK001 Pan Caspase Inhibitor Z-VAD-FMK 1mg

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