PeproTech 315-11-2，Recombinant Murine sRANK Ligand，规格：2µg，运输：4°C，保存：-20°C

soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

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货品编号：PeproTech.315-11-2

数量： -+ 支

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品牌：Peprotech
所属分类：细胞因子

货品编号：PeproTech.315-11-2    品牌：Peprotech
    规格：2µg
 
    别名:
<div>    soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)
 
    描述:
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone
 turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. 
These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate
 T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal
cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis
by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. 
Recombinant Murine sRANKL is a 19.4 kDa polypeptide comprising the TNF-homologous region of RANKL (174 amino acid residues).
 
    氨基酸序列:
   PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT
   LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR
   HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN
   WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ
   DATYFGAFKV QDID
 
    来源: E.coli 
 
    纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses. 
 
    生物活性: Determined by its ability to induce NF-κB in RAW264.7 cells in the absence of any cross-linking. 
                   The expected ED50 for this effect is 10.0-25.0 ng/ml. 
 
    交叉反应: Human, Rat, Mouse
 
    研究领域：
</div><blockquote style="margin: 0px 0px 0px 40px; border: none; padding: 0px;"><div><table width="600" style="text-align: center;" border="1" cellspacing="1" cellpadding="1"><tbody><tr><td>  
<img width="43" height="43" title="细胞凋亡" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="细胞凋亡" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-apoptosis.jpg"></td><td> 细胞凋亡</td><td>  
<img width="43" height="43" title="骨，骨骼，软骨" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="骨，骨骼，软骨" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-bone-skeletal-cartilage.jpg"></td><td> 骨，骨骼，软骨</td></tr><tr><td>  
<img width="43" height="43" title="癌症" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="癌症" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-cancer.jpg"></td><td> 癌症</td><td>  
<img width="43" height="43" title="糖尿病/ 体重调节" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="糖尿病/ 体重调节" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-diabetes.jpg"></td><td> 糖尿病/体重调节</td></tr><tr><td>  
<img width="43" height="43" title="免疫系统" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="免疫系统" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-immune_system.jpg"></td><td> 免疫系统</td><td>  
<img width="43" height="43" title="TNF超家族" class="floatright-not" style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; line-height: 16.8px; border-style: none; margin-bottom: 2px; text-align: right; padding-top: 2px;" alt="TNF超家族" src="https://www.peprotech.com/PublishingImages/ResearchInterest/ri-tnf_superfamily.jpg"></td><td> TNF超家族</td></tr></tbody></table></div> 
</blockquote>    原产国：USA 
    仅用于研究。不适用于诊断或治疗。

PeproTech 315-11-2，Recombinant Murine sRANK Ligand，规格：2µg，运输：4°C，保存：-20°C

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