Peprotech 450-14-50 Human Osteoprotegerin 50ug

Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL.

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货品编号：Peprotech.450-14-50

数量： -+ 50UG/支

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品牌：Peprotech
所属分类：细胞因子检测

货品编号：  Peprotech.450-14-50
     品牌：  Peprotech
     品名：  Human Osteoprotegerin
     规格：  50UG/支
 
     产品描述
     Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL.       Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between      stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage.  
     OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, 
     lymph node, and bone marrow. 
     OPG is secreted both as a monomeric and a dimeric protein.  Its primary structure consists of seven distinct 
     domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute 
     the soluble OPG.  
     Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues. 
 
     氨基酸序列:
<div class="productitemright" id="ctl00_SPWebPartManager1_g_84baceb0_a98e_464f_829a_c4bd20da1bc8_ctl00_divSequenceText">     METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL  
<div class="productitemright">     QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC </div><div class="productitemright">     RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK </div><div class="productitemright"> </div><div class="productitemright">     纯度      Greater than 98% by SDS-PAGE gel and HPLC analyses. 
 
     生物活性      Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL (sRANKL). 
 
     交叉反应      Mouse, Rat, Human 
 
 
</div></div>

Peprotech 450-14-50 Human Osteoprotegerin 50ug

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