sigma M5250-1g 褪黑素 1g

sigma M5250-1g 褪黑素

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货品编号：sigma.M5250-1g

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品牌：Sigma-Aldrich
所属分类：褪黑素

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     货品编号：    sigma.M5250-1g
     品牌：  sigma
     品名：  褪黑素 
     规格：  1g
 
     Application      Melatonin has been administered to experimental animals for following studies:      • To determine if long-term melatonin administration is able to induce reproductive changes and how melatonin 
     exerts its protective action related to lipid oxidation and antioxidant activities in the rat ovary during ovulation.      • To determine the effect of melatonin on endoplasmic reticulum stress and sirtuin 1 expression in neuronal cells
     of newborn rats after hypoxia–ischemia.      • To study the effect of melatonin on chronic stress-induced gut dysfunction in stressed mice.[4]
 
     Biochem/physiol Actions      Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. 
     Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing 
     apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor 
     action.      Melatonin is characterized with variety of properties such as antioxidant, autocoid, paracoid and hormonal properties, as 
     well as anti- inflammatory and anti-apoptotic properties. Melatonin is implicated in the regulation of seasonal reproduction,
     energy metabolism and thermoregulation in mammals.
     Melatonin plays a vital role in the lessening of neonatal hypoxia–ischemia (HI) induced endoplasmic reticulum (ER) stress 
     and conserves sirtuin 1( SIRT-1) expression. 
 
     Features and Benefits      This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically 
     annotated collection of high-quality, ready-to-screen compounds. Click here to learn more. 
 
     General description      Melatonin (N-acetyl-5-methoxytryptamine) is synthesized from an essential amino acid tryptophan. It is a pineal gland neurohormone.
     Direct, non-receptor-mediated free radical scavenging activity induced by melatonin, makes it unique from other classic hormones. 
     Melatonin is expressed in variety of organisms such as bacteria, algae, fungi
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sigma M5250-1g 褪黑素 1g

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