Sigma P8139-1mg Phorbol 12-myristate 13-acetate

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

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货品编号：Sigma.P8139-1mg

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     货品编号：  Sigma.P8139-1mg      品牌：  Sigma      品名：  Phorbol 12-myristate 13-acetate       规格： 1mg</div> 
     Biochem/physiol Actions      Potent tumor promoter; activates protein kinase C in vivo and in vitro. 
 
     Caution      Photosensitive 
 
     Application      Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent 
     lymphocytes and fetal thymocytes.[2][3][4] It has also been used for the activation of PKC (protein kinase C) in cells.[5] 
 
     Features and Benefits      This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a 
     biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more. 
 
     This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To
     browse other handbook pages, click here. 
 
     General description      Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell
     growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) 
     signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and 
     cytokines-mediated regulation of cellular growth and differentiation.[1]

Sigma P8139-1mg Phorbol 12-myristate 13-acetate

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