signalchem.B10-12CH-05 BTK (C481S), Active 5ug

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货品编号：signalchem.B10-12CH-05

数量： -+ 支

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品牌：SignalChem
所属分类：工具酶

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</div>     货品编号：  signalchem.B10-12CH-05       品牌：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">signalchem      品名：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">BTK (C481S), Active       规格：  <span style="background-color: transparent; color: rgb(0, 0, 0); cursor: text; display: inline; float: none; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">5ug          产品描述：       Description: Recombinant full-length human BTK (C481S) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.      Species: Human      Tag: His tag      Expression System: Sf9 insect cells using baculovirus      Sequence: Full Length (C481S)      Genbank Number: NM_000061         Specific Activity : Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. <div>     
<img height="90" style="background-color: transparent; color: rgb(116, 113, 113); font-family: Calibri; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;" src="https://www.signalchem.com/shared_images/smBTK-C481S_G1234-5activity.gif"></div>      Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. <div>     
<img height="90" style="background-color: transparent; color: rgb(116, 113, 113); font-family: Calibri; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;" src="https://www.signalchem.com/shared_images/smBTK-C481S_G1234-5gel.gif"></div>      torage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and      store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.      Applications : Kinase Assay, Western Blot      Molecular Weight : ~75kDa      Gene Aliases : AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK      Formulation : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.      Scientific Background : BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK     interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1).Defects in     the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells      and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer,      anti-inflammatory and anti-viral agents as well as other treatments (2). <strike></strike>

signalchem.B10-12CH-05 BTK (C481S), Active 5ug

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