BioXcell.BE0131-25MG InVivoMab anti-mouse CTLA-4 (CD152)

     产品描述：
     The 9H10 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. 

     CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. 

     CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, 

     CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 

     negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological

     tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation

     has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a 

     lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through 

     immune checkpoint blockade. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to

     the B7 co-receptors, allowing for CD28 binding.