apexbio.B8214 Dihydrotestosterone(DHT) 25mg

     货品编号：  apexbio.B8214

     品牌：  apexbio

     品名：  Dihydrotestosterone(DHT)   

     规格：  25mg

     产品描述：

     Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor .

     In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increases the expression of EGFR 

     and ERBB2 both in mRNA and in protein levels. In AR-positive cell，DHT additionally upregulates the levels of phosphorylation

     of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment.

     DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with 

     stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert 

     myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction

     denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior

     as assessed by rota-rod and gait analyses, and an increased lifespan.