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  • PeproTech 315-11-10,Recombinant Murine sRANK Ligand,规格:10µg,运输:4°C,保存:-20°C

PeproTech 315-11-10,Recombinant Murine sRANK Ligand,规格:10µg,运输:4°C,保存:-20°C

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        货品编号:PeproTech.315-11-10

        品牌:Peprotech

        规格:10µg

     

        别名:

        soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

     

        描述:

        RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone

     turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. 

    These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate

     T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal

    cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis

    by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. 

    Recombinant Murine sRANKL is a 19.4 kDa polypeptide comprising the TNF-homologous region of RANKL (174 amino acid residues).

     

        氨基酸序列:

       PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT

       LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR

       HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN

       WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ

       DATYFGAFKV QDID

     

        来源: E.coli 

     

        纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses. 

     

        生物活性: Determined by its ability to induce NF-κB in RAW264.7 cells in the absence of any cross-linking. 

                       The expected ED50 for this effect is 10.0-25.0 ng/ml. 

     

        交叉反应: Human, Rat, Mouse

     

        研究领域:

      细胞凋亡 细胞凋亡  骨,骨骼,软骨 骨,骨骼,软骨
      癌症 癌症  糖尿病/ 体重调节 糖尿病/体重调节
      免疫系统 免疫系统  TNF超家族 TNF超家族

     

        原产国:USA

     

        仅用于研究。不适用于诊断或治疗。