PeproTech 315-02-10，Recombinant Murine M-CSF，规格：10µg，运输：4°C，保存：-20°C

    Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

    描述:

    M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells,

 myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages,

 and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. 

M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation.

 Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. 

Recombinant Murine M-CSF is a 36.4 kDa homodimeric protein consisting of two 156 amino acid polypeptide subunits.

    氨基酸序列:

   MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD

   QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER 

   LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN 

   FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

    来源: E.coli 

    纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses.

    生物活性: he ED50 as determined by the dose-dependent stimulation of the proliferation of M-NFS-60 cells is ≤ 1.0 ng/ml,

                   corresponding to a specific activity of ≥ 1 x 106 units/mg.

    交叉反应: Mouse, Human, Rat

    研究领域：