sigma M5250-1g 褪黑素 1g

     货品编号：    sigma.M5250-1g

     品牌：  sigma

     品名：  褪黑素 

     规格：  1g

     Application
     Melatonin has been administered to experimental animals for following studies:
     • To determine if long-term melatonin administration is able to induce reproductive changes and how melatonin

     exerts its protective action related to lipid oxidation and antioxidant activities in the rat ovary during ovulation.
     • To determine the effect of melatonin on endoplasmic reticulum stress and sirtuin 1 expression in neuronal cells

     of newborn rats after hypoxia–ischemia.
     • To study the effect of melatonin on chronic stress-induced gut dysfunction in stressed mice.[4]

     Biochem/physiol Actions
     Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger.

     Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing

     apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor

     action.
     Melatonin is characterized with variety of properties such as antioxidant, autocoid, paracoid and hormonal properties, as

     well as anti- inflammatory and anti-apoptotic properties. Melatonin is implicated in the regulation of seasonal reproduction,

     energy metabolism and thermoregulation in mammals.

     Melatonin plays a vital role in the lessening of neonatal hypoxia–ischemia (HI) induced endoplasmic reticulum (ER) stress

     and conserves sirtuin 1( SIRT-1) expression.

     Features and Benefits
     This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically

     annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

     General description
     Melatonin (N-acetyl-5-methoxytryptamine) is synthesized from an essential amino acid tryptophan. It is a pineal gland neurohormone.

     Direct, non-receptor-mediated free radical scavenging activity induced by melatonin, makes it unique from other classic hormones.

     Melatonin is expressed in variety of organisms such as bacteria, algae, fungi