BIOXCELL.BE0189-1mg anti-human CD40

     货品编号：  BIOXCELL.BE0189-1mg    
     品牌：  BIOXCELL
     品名：  anti-human CD40
     规格：  1mg    

     产品描述：

     The G28.5 monoclonal antibody reacts with human CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane 

     glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on 

     antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune 

     endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory 

     molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, 

     differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies 

     have been shown to activate APCs and promote anti-tumor T cell responses. The G28.5 antibody is an agonistic antibody that

     has been shown to activate CD40 expressing APCs.